1+ day, 5+ hour ago  (1426+ words) Data are presented as mean'SEM. Individual data points represent single observations. The number of cells (n) and the number of animals (N) are indicated in the figure legends. Statistical significance was set at " To investigate potential cell-type differences in the effects of…...

9+ mon, 2+ week ago  (181+ words) Explore research topics across seven scientific disciplines. Search and discover topics from Applied sciences, Biological sciences, Chemistry, Earth & environmental sciences, Health sciences, Physical sciences, and Social sciences. View the latest institution rankings View the latest Country/territory rankings The Nature…...

2+ day, 9+ hour ago  (1453+ words) Mental illnesses are among the top contributors to the worldwide disease burden and economic impact. The Global Burden of Disease study indicates that neuropsychiatric conditions consistently rank among the top ten causes of years lived with disability worldwide, with no…...

2+ day, 13+ hour ago  (60+ words) Nature Mental Health (2026)Cite this article In this World View, Constanza Mor'n, a biomedical researcher and daughter of a man with schizophrenia, calls for humility and collaboration to bridge the divide between biological psychiatry and anti-psychiatry, improving support for patients…...

2+ day, 15+ hour ago  (868+ words) Using 20222023 nationally representative data, we examined the following questions and our hypothesis: What is the national prevalence of overall and moderate-severe polysubstance use disorders? How does the prevalence vary by age of initiation of overall and specific substance use? What…...

3+ day, 5+ hour ago  (1788+ words) Male FVB129 Fmr1-KO and FVB129 wild-type (WT) mice were bred in-house, weaned at P21 and group-housed (12-h light/dark cycle; food and water ad libitum) with same-sex littermates. Protocols were approved by the Institutional Animal Care and Use Committee (IACUC) and were consistent…...

3+ day, 5+ hour ago  (1627+ words) Kahn RS. On the Origins of Schizophrenia. Am J Psychiatry. 2020; 177: 2917. Kahn RS, Keefe RS. Schizophrenia is a cognitive illness: time for a change in focus. JAMA Psychiatry. 2013; 70: 110712. Bora E, Murray RM. Meta-analysis of cognitive deficits in ultra-high risk to psychosis…...

3+ day, 16+ hour ago  (1829+ words) Exosomes can traverse or influence the BBB under specific physiological and pathological contexts. While BBB permeability alterations are reported in subsets of depressed patients and in stress models, the quantitative contribution of vesicle trafficking to central'peripheral immune crosstalk remains an…...

4+ day, 12+ hour ago  (1698+ words) Cx43 protein levels were extracted from the processed dataset for targeted comparison between groups. Differences between SCZ and Ctrl subjects were assessed using an unpaired two-tailed t-test. Data are presented as mean'SEM, and p The schizophrenia model was induced in postnatal…...

1+ week, 6+ hour ago  (1785+ words) Approval to undertake the study was obtained from the Ethics Committee of the University of Bonn, Medical Faculty (Lfd. Nr. : 338/15). The study is carried out in accordance with the recommendations of the International Conference on Harmonization Good Clinical Practice standards....