19+ hour, 25+ min ago  (212+ words) Fucosidosis is an exceptionally rare autosomal recessive lysosomal storage disorder caused by deficiency of α-L-fucosidase due to pathogenic variants in the FUCA1 gene. Neurologic involvement is prominent, and magnetic resonance imaging (MRI) frequently provides early diagnostic clues through characteristic white matter…...

4+ day, 19+ hour ago  (344+ words) A 16-year-old post-pubertal female presented with mixed anxiety-depressive symptoms, prominent obsessive rumination, relationship-centered guilt, reassurance-seeking, fantasy intrusions, and difficulty separating fantasy from reality during periods of distress. Baseline scores were in the moderate range for depression and severe range for…...

6+ day, 19+ hour ago  (217+ words) The intersection of pediatric psychiatry and infectious disease can present complex diagnostic challenges, particularly when symptoms of organic medical etiology mimic severe psychiatric disorders. This case study analyzes the clinical trajectory of an adolescent patient who developed delirious mania - a…...

1+ week, 2+ day ago  (297+ words) Lithium remains a cornerstone in the treatment of bipolar I disorder because of its well-established efficacy in reducing mood episode recurrence and suicide risk. However, its narrow therapeutic index makes patients particularly susceptible to clinically significant toxicity, especially following medication…...

1+ week, 3+ day ago  (321+ words) Background Psychiatric EDs manage high volumes of patients who often face barriers to medication access, limited understanding of discharge instructions, and difficulty securing timely outpatient follow-up. Structured early outreach has shown promise in improving these transitions. This quality improvement initiative…...

1+ week, 4+ day ago  (150+ words) Located along the third ventricle of the hypothalamus, tanycytes are a type of glial cell that are prominent components of metabolic, homeostatic, and immunological signaling and transport. Behavioral deficits observed in disorders such as anorexia nervosa (AN), schizophrenia (SCZ), and…...

3+ week, 5+ day ago  (273+ words) Research has failed to demonstrate that depression is caused by a deficit in central serotonin activity. Umbrella reviews show no consistent association between serotonin markers and major depressive disorder (MDD), and routine clinical practice does not measure serotonin before treatment. Selective…...

1+ mon, 1+ day ago  (172+ words) Lithium has a narrow therapeutic index and remains the first-line treatment for bipolar I and II disorders. Dosing this medication requires careful monitoring, and there is a risk of toxicity. This case follows a 43-year-old male with a medical history…...

1+ mon, 2+ week ago  (295+ words) Antibiotic-induced manic episodes describe the emergence of manic or hypomanic symptoms during or shortly after antimicrobial therapy. Although uncommon, these reactions are clinically important because they may be misattributed to primary bipolar disorder, delirium, or neuropsychiatric effects of infection. Hence,…...

1+ mon, 2+ week ago  (418+ words) Background: Obsessive-compulsive disorder (OCD) and allergic diseases co-occur far more often than expected, yet genome-wide genetic correlations are typically modest or negative. The objective of this study was to test whether OCD and allergic diseases show convergence at the level…...