4+ hour, 11+ min ago  (714+ words) Summary: Schizophrenia and psychosis do not follow a single, predictable path. A landmark 10-year study has mapped the complex interaction between brain maturation, medication, and cognitive symptoms in 357 patients. Source: University of Seville Researchers at the University of Seville have…...

2+ day, 23+ hour ago  (1188+ words) Source: Imperial College London People with major depressive disorder saw significant and lasting reductions in their symptoms from a single dose of the psychedelic compound DMT in a'small study. In the Phase IIa randomised clinical trial, led by researchers at…...

6+ day, 3+ hour ago  (615+ words) The findings suggest that OCD symptoms may be driven by abnormal frontal brain circuitry and open the door to more precise, responsive DBS systems that activate only when pathological signals appear. A specific pattern of brain activity in a frontal…...

1+ mon, 3+ week ago  (1034+ words) It also revealed a set of "incongruent neurons" that predicted errors, a signal researchers only recognized in their animal data after the model exposed it. This biomimetic platform provides a powerful blueprint for exploring disease-related circuit changes and testing therapeutic…...

2+ mon, 1+ week ago  (1063+ words) Summary: New research shows that rats with naturally higher baseline stress hormone levels are significantly more likely to self-administer cannabis vapor. Over several weeks, rats were allowed to nose-poke for cannabis, and those with elevated corticosterone displayed the strongest drug-seeking…...

2+ mon, 1+ week ago  (564+ words) The findings highlight a distinct biological subtype of depression shaped by immune dysregulation, offering a potential path toward more personalized treatment. Future work will focus on identifying biomarkers that reliably predict who will benefit and on developing safer, targeted anti-inflammatory…...

3+ mon, 1+ day ago  (864+ words) Summary: A large international survey of 858 electroconvulsive therapy recipients found that women are twice as likely as men to receive ECT and experience more adverse effects. Women reported higher rates of memory loss, greater feelings of coercion, and more harmful…...

3+ mon, 2+ day ago  (996+ words) Summary: A massive international genetic study has uncovered rare, high-effect variants in three specific genes'MAP1A, ANO8 and ANK2'that dramatically increase the likelihood of developing ADHD. These variants, though extremely uncommon, strongly affect genes expressed in dopaminergic and GABAergic neurons, influencing brain…...

3+ mon, 3+ day ago  (936+ words) Summary: A new study identifies the orbitofrontal cortex (OFC) as a crucial brain region for inference-making, allowing animals to interpret hidden states in changing environments. Researchers trained rats to wait for water rewards that varied in predictable but concealed patterns,…...

3+ mon, 6+ day ago  (740+ words) Summary: New research shows that depression beginning before age 25 has a much stronger hereditary component than depression that emerges later in life. By analyzing genetic data from over 150,000 people with depression, researchers identified distinct genetic regions linked specifically to early-onset…...