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Disruption of Reelin signaling in a dual-hit mouse model of schizophrenia: impact of postnatal Î9-tetrahydrocannabinol exposure in a maternal immune activation model | Translational Psychiatry
5+ hour, 40+ min ago (134+ words) Spanish Network for Research in Mental Health (CIBERSAM, ISCIII), Monforte de Lemos AV, 3-5, 28029, Madrid, Spain Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio (Bizkaia), Spain; Center for Biomedical Research in…...
Acute alcohol triggers rank-specific social ascent through a prefrontal-accumbens circuit in male mice | Neuropsychopharmacology
6+ hour, 48+ min ago (1005+ words) Receive 13 print issues and online access only $19.92 per issue All data are available from the authors upon reasonable request. LeClair KB, Russo SJ. Using social rank as the lens to focus on the neural circuitry driving stress coping styles. Curr…...
In memoriam – Ming T. Tsuang, M.D., Ph.D., D.Sc - Neuropsychopharmacology
1+ week, 1+ day ago (113+ words) Ming T. Tsuang passed away peacefully at his home in La Jolla, CA, USA, on March 18, 2026, at the age of 94. Professor Tsuang was a Fellow Emeritus of the ACNP and was accepted into membership in 1993. Department of Psychiatry and Behavioral Sciences,…...
The promise of digital phenotyping for the early detection of risk for depression in adolescents | Nature Mental Health
1+ week, 6+ day ago (284+ words) Nature Mental Health (2026) Cite this article Advances in consumer wearables and machine learning enable the continuous detection of depression risk through behavioral and physiological data. In this Comment, we emphasize the crucial need to apply these technologies to adolescents, highlighting…...
Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder | Molecular Psychiatry
2+ week, 3+ day ago (1781+ words) Molecular Psychiatry (2026) Cite this article The UK Biobank (UKB) is a population health cohort study [39]. Our dataset included a subset of UKB participants who completed the first Mental Health Questionnaire (MHQ1) [40]. The MHQ1 provided only brief measures for fear disorders and both…...
Transforming psychiatry with computational and brain-based methods - Nature Computational Science
9+ mon, 6+ day ago (313+ words) Goldstein-Piekarski, A. N. et al. Biol. Psychiatry 91, 561–571 (2022). Tozzi, L. et al. Nat. Med. 30, 2076–2087 (2024). Akiki, T. et al. Biol. Psychiatry 97, S160–S161 (2025). Genin, K., Grote, T. & Wolfers, T. Synthese 204, 88 (2024). Rutherford, S. et al. eLife 11, e72904 (2022). Tejavibulya, L. et al. Mol. Psychiatry 27, 3129–3137 (2022). Twist, K. et al. Psychosom....
Modulation of early non-rapid eye movement slow wave activity by ketamine in treatment-resistant depression - Neuropsychopharmacology
1+ mon, 52+ min ago (1388+ words) Compared to HVs, TRD patients exhibited significantly lower NREM1 SWA at baseline (HVs: 1.40 ± 0.05; TRD: 1.11 ± 0.03, mean ± SEM; Welch’s ttest, t = −5.17, p As a secondary analysis, a linear mixed-effects model revealed no effect of condition on NREM1 SWA in HVs (F(2,79) = 0.11, p = 0.898). Neither ketamine (β…...
Distinct contributions of schizophrenia and neurotransmitter pathway genetic liability to neurocognition and antipsychotic efficacy in drug-naïve first-episode schizophrenia | Molecular Psychiatry
1+ mon, 1+ day ago (1618+ words) Molecular Psychiatry (2026) Cite this article The data supporting the findings of this study are not publicly available due to legal and ethical restrictions related to participant consent and data protection regulations. However, de-identified summary data are available from the corresponding…...
IN MEMORIUM - Roger E. Meyer, MD - Neuropsychopharmacology
1+ mon, 4+ day ago (209+ words) Roger was recruited by the University of Connecticut in 1977 where he became Chair of the Department of Psychiatry and developed and led a NIAAA funded Alcohol Research Center (1978–1993). From 1989 to 1992, he also served as Executive Dean at UConn. He spent…...
Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen - Molecular Psychiatry
1+ mon, 4+ day ago (1793+ words) Molecular Psychiatry (2026) Cite this article The convergence of these findings suggests that PRS are best viewed not as standalone diagnostic tools, but as scalable instruments for risk stratification, enrichment of prevention trials, and dissection of AD heterogeneity when integrated with…...