1+ hour, 1+ min ago  (1698+ words) This study investigates the frequency and intensity of ADR during AD therapy in a cohort of hospitalized psychiatric patients regarding their CYP2 C19 and CYP2 D6 functional status. Pharmacodynamic and pharmacokinetic factors were considered. Furthermore, a drug-specific subgroup analysis was performed for VEN. Patients…...

3+ hour, 55+ min ago  (1709+ words) Nature Mental Health (2026)Cite this article only $6. 58 per issue Friedrich, M. J. Depression is the leading cause of disability around the world. JAMA 317, 1517 (2017). Bernaras, E. , Jaureguizar, J. & Garaigordobil, M. Child and adolescent depression: a review of theories, evaluation instruments, prevention programs, and treatments. Front. Psychol....

8+ hour, 21+ min ago  (1816+ words) 16 S r RNA gene sequence data are available in the Sequence Read Archive (SRA) under Bio Project accession PRJNA1127822 and PRJNA1127800. Huang Y, Wang Y, Wang H, Liu Z, Yu X, Yan J, et al. Prevalence of mental disorders in China: a…...

1+ day, 1+ hour ago  (1745+ words) A shows alteration in state of consciousness after single doses of MDMA (adapted from [57, 58, 59]). B shows a circular map of subjective effects that are frequently reported after a single dose of MDMA (75125mg) in placebo controlled clinical trials in healthy volunteers....

1+ day, 15+ hour ago  (632+ words) This work was supported by the Swedish Research Council (2024-02542). Open access funding provided by Karolinska Institute. Department of Basal and Clinical Neuroscience, King's College London, London, UK DD, AC and PS conceived, drafted and approved the final version of this…...

1+ day, 8+ hour ago  (152+ words) Diagnostic and statistical manual of mental disorders: DSM-5, 5th ed. (American Psychiatric Publishing, Inc. , 2013). This work was supported by the National Institute of Mental Health (NIMH) (grants U01 MH108898 and R01 MH124890 to J. G. G.), a grant from the Larry L. Hillblom Foundation (to J. G. G.), and the 2021 NARSAD Young…...

2+ day, 11+ hour ago  (1797+ words) We further evaluated concordance of genes prioritized across the four approaches. For each of the six brain phenotypes, we used Jaccard similarity index to compare similarity of genes identified. The Jaccard index, defined as the size of the intersection divided…...

1+ day, 23+ hour ago  (1683+ words) Across both individual cell lines and the playground model, we patch-clamped 997 neurons (Supplementary Fig. 4), analysed 5, 168 MEA electrodes from 323 wells recording the activity of neurons weekly over three months (Supplementary Fig. 5) and imaged 2, 565, 549 neurons from 304 wells with a high-content confocal microscope…...

2+ day, 15+ hour ago  (529+ words) Miryam Naddaf is a reporter for Nature in London. Different psychedelic drugs have a strikingly similar effect on networks in the brain, finds the most comprehensive analysis so far of the mind-altering substances. The work, published in Nature Medicine on…...

3+ day, 15+ hour ago  (1516+ words) Psychedelic drugs are re-emerging as promising scientific and clinical tools. However, despite a rapidly expanding literature on their therapeutic value, the neural mechanisms underlying psychedelic effects remain unclear. Resting-state functional magnetic resonance imaging studies of acute psychedelic effects, conducted independently…...