News
Biobehavioral Markers May Improve Antidepressant Response in Major Depressive Disorder
6+ hour, 28+ min ago (267+ words) Researchers developed predictive algorithms using response markers for sertraline and bupropion derived from the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) multisite trial. Model performance during leave-one-out cross-validation was favorable, with area under the curve (AUC)…...
Algorithm-Guided Treatment Improves Outcomes in Major Depressive Disorder
3+ mon, 2+ day ago (248+ words) The review, conducted by investigators from Aalborg University Hospital in Denmark and collaborators, examined evidence comparing AGT with TAU in MDD management. AGT refers to structured, stepwise treatment protocols that guide clinicians on when and how to modify therapy based…...
Psilocybin Produces Mixed Outcomes in Phase 2b MDD Study
3+ mon, 2+ week ago (162+ words) The EPISODE trial was conducted at 2 outpatient centers in Germany by investigators affiliated with Heidelberg University, the Central Institute of Mental Health, and Charité-Universitätsmedizin Berlin. Safety findings were more complex. Severe adverse events occurred in 28% of cases after psilocybin 25 mg…...
Considerations for Selecting an Antidepressant in Major Depressive Disorder
3+ mon, 2+ week ago (144+ words) Kristian Dambrino, DNP, PMHNP-BC: Hi, I'm Kristian Dambrino. I'm a doctor of nursing practice, practicing and living in Nashville, Tennessee at Dambrino Consulting and Wellness. I'm also adjunct faculty at Belmont University College of Nursing, and I'm a Fulbright Scholar....
Enhanced Prenatal Care Models Improve Perinatal Depression Scores
3+ mon, 3+ week ago (271+ words) The analyzed cohort included 674 participants with a mean age of 27.0 years (standard deviation [SD] 5.8) and was predominantly Latine (72.0%), with additional representation from African American or Black (7.4%), White (11.4%), biracial or multiracial (5.5%), and other racial or ethnic groups (3.6%). Participants were randomized to…...
AMPA Receptor Modulation Shows Promise in Major Depressive Disorder Treatment
3+ mon, 3+ week ago (275+ words) Findings from the research poster that summarized data supporting the role of AMPA receptors in the pathophysiology of MDD emphasize that current monoamine-based antidepressants often fail to produce meaningful improvement, leaving patients with persistent symptoms such as low mood, reduced…...
Clozapine Shows Superior Response After First Antipsychotic Failure
3+ mon, 3+ week ago (304+ words) Response rates differed significantly across treatments (χ² = 18.3; P =.001). Risperidone (63.4%) and amisulpride (61.8%) demonstrated the highest efficacy, followed by olanzapine (60.5%). Lower response rates were observed with aripiprazole (44.3%) and perphenazine (45.7%). In the second phase, 111 nonresponders were rerandomized to olanzapine (n=41), amisulpride (n=38), or clozapine (n…...
Systematic Review Links Negative Symptoms in Schizophrenia to Lower Quality of Life and Function
5+ mon, 4+ day ago (166+ words) In individuals with schizophrenia, greater severity of negative symptoms was associated with decreased health-related quality of life (HRQoL) and worse functional outcomes, according to a systematic review published in Schizophrenia Research. Across the studies, the Positive and Negative Syndrome Scale…...