7+ hour, 35+ min ago  (271+ words) The analyzed cohort included 674 participants with a mean age of 27.0 years (standard deviation [SD] 5.8) and was predominantly Latine (72.0%), with additional representation from African American or Black (7.4%), White (11.4%), biracial or multiracial (5.5%), and other racial or ethnic groups (3.6%). Participants were randomized to…...

1+ day, 4+ hour ago  (275+ words) Findings from the research poster that summarized data supporting the role of AMPA receptors in the pathophysiology of MDD emphasize that current monoamine-based antidepressants often fail to produce meaningful improvement, leaving patients with persistent symptoms such as low mood, reduced…...

5+ day, 2+ hour ago  (304+ words) Response rates differed significantly across treatments (" = 18.3; P = .001). Risperidone (63.4%) and amisulpride (61.8%) demonstrated the highest efficacy, followed by olanzapine (60.5%). Lower response rates were observed with aripiprazole (44.3%) and perphenazine (45.7%). In the second phase, 111 nonresponders were rerandomized to olanzapine (n=41), amisulpride (n=38), or clozapine…...

1+ mon, 1+ week ago  (166+ words) In individuals with schizophrenia, greater severity of negative symptoms was associated with decreased health-related quality of life (HRQoL) and worse functional outcomes, according to a systematic review published in Schizophrenia Research." Across the studies, the Positive and Negative Syndrome Scale…...