13+ hour, 44+ min ago  (37+ words) Cureus Please note that by doing so you agree to be added to our monthly email newsletter distribution list. Download Cureus Media Kit...

14+ hour, 54+ min ago  (254+ words) Introduction: Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia but remains underutilized due to safety concerns and monitoring complexity. Recent discontinuation of the Clozapine Risk Evaluation and Mitigation Strategy (REMS) program reduced regulatory barriers but shifted responsibility for monitoring…...

1+ day, 10+ hour ago  (275+ words) Major depressive disorder (MDD) remains one of the leading causes of disability worldwide, and a substantial proportion of patients do not achieve remission with standard pharmacological treatments. In this context, repetitive transcranial magnetic stimulation (r TMS) has gained increasing clinical recognition…...

1+ day, 17+ hour ago  (37+ words) Cureus Please note that by doing so you agree to be added to our monthly email newsletter distribution list. Download Cureus Media Kit...

3+ day, 7+ hour ago  (244+ words) While the clinical archetype of 3, 4-methylenedioxymethamphetamine (MDMA) toxicity is traditionally associated with young individuals in nightlife environments, particularly in nightclubs and rave settings, its emerging role in therapeutic research may contribute to increasing unsupervised use. As MDMA gains mainstream attention…...

2+ day, 21+ hour ago  (470+ words) Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric condition. While selective serotonin reuptake inhibitors (SSRIs) are a standard treatment, many patients experience an inadequate response to monotherapy. For individuals with treatment-resistant OCD (TR-OCD), antipsychotic augmentation is a commonly utilized pharmacological strategy....

1+ week, 4+ day ago  (235+ words) Background: Antipsychotic medications are associated with QT interval prolongation and an increased risk of serious arrhythmias. Clinical guidelines, therefore, recommend baseline electrocardiogram (ECG) monitoring prior to initiation. This audit evaluated the compliance of baseline ECG monitoring before the initiation of…...

1+ week, 6+ day ago  (327+ words) Major depressive disorder (MDD) is a leading cause of global disability, with fewer than half of patients achieving remission following first-line antidepressant treatment. Inflammatory processes have been implicated in MDD, but the extent to which baseline inflammatory markers predict treatment outcomes…...

1+ week, 5+ day ago  (290+ words) Developing and evaluating non-pharmacological treatments is critical for optimizing pain management and reducing dependence on opioids, as well as mitigating opioid-induced adverse effects. One promising approach involves the use of virtual reality (VR)- and augmented reality (AR)-guided mindfulness techniques....

2+ week, 2+ day ago  (260+ words) Background Depression is a multifactorial neuropsychiatric disorder involving alterations in neuroplasticity, neurotransmission, and oxidative stress. Zebrafish larvae are a useful model for studying stress-induced behavioral changes. Pithecellobium dulce, rich in bioactive phytochemicals, has reported antioxidant properties, but its effects in…...