13+ hour, 44+ min ago  (150+ words) Located along the third ventricle of the hypothalamus, tanycytes are a type of glial cell that are prominent components of metabolic, homeostatic, and immunological signaling and transport. Behavioral deficits observed in disorders such as anorexia nervosa (AN), schizophrenia (SCZ), and…...

2+ week, 1+ day ago  (273+ words) Research has failed to demonstrate that depression is caused by a deficit in central serotonin activity. Umbrella reviews show no consistent association between serotonin markers and major depressive disorder (MDD), and routine clinical practice does not measure serotonin before treatment. Selective…...

2+ week, 6+ day ago  (172+ words) Lithium has a narrow therapeutic index'and remains the first-line treatment for bipolar I and II disorders. Dosing this medication requires careful monitoring, and there is a risk of toxicity. This case follows a 43-year-old male with a medical history of…...

1+ mon, 6+ day ago  (295+ words) Antibiotic-induced manic episodes describe the emergence of manic or hypomanic symptoms during or shortly after antimicrobial therapy. Although uncommon, these reactions are clinically important because they may be misattributed to primary bipolar disorder, delirium, or neuropsychiatric effects of infection. Hence,…...

1+ mon, 1+ week ago  (418+ words) Background: Obsessive-compulsive disorder (OCD) and allergic diseases co-occur far more often than expected, yet genome-wide genetic correlations are typically modest or negative. The objective of this study was to test whether OCD and allergic diseases show convergence at the level…...

1+ mon, 1+ week ago  (43+ words) Comparative Augmentative Efficacy of Second-Generation Antipsychotics in Adult Treatment-Resistant Depression: A Systematic Review The Cureus Journal of Medical Science Please note that by doing so you agree to be added to our monthly email newsletter distribution list. Download Cureus Media…...

1+ mon, 2+ week ago  (37+ words) Cureus Please note that by doing so you agree to be added to our monthly email newsletter distribution list. Download Cureus Media Kit...

1+ mon, 2+ week ago  (330+ words) Clozapine is the most effective treatment for treatment-resistant schizophrenia, offering significant therapeutic benefits for patients who have failed to respond to other antipsychotic regimens. However, its clinical use is limited by the risk of severe hematological adverse events, particularly neutropenia…...

1+ mon, 2+ week ago  (363+ words) Cardiovascular disease (CVD) comorbidity in mental health underpins the basis of referrals to cardiology specialists in mental healthcare, while blood flow issues constitute part of the pathophysiology. However, there is a dearth of data on evidence-based cardiovascular medicine in mental healthcare,…...

1+ mon, 3+ week ago  (342+ words) In many settings, postgraduate psychiatry training now emphasizes neuroscience, evidence-based treatment, diagnostic criteria, and structured psychological models. These advances have improved psychiatric care in important ways. They have strengthened diagnosis, expanded treatment options, and improved scientific understanding of mental illness....