3+ hour, 44+ min ago  (169+ words) Lower cognition is associated with later depression in controls, while higher cognition is associated with relapse in remitted depression Participants with remitted depression had a higher risk of future depression compared with matched controls, while baseline cognitive performance was associated…...

1+ week, 3+ day ago  (197+ words) Psychotic-like experiences were assessed using the Prodromal Questionnaire'Brief Child Version (PQ-BC), a self-report screening instrument measuring subclinical symptoms such as unusual perceptions, suspiciousness, and odd beliefs rather than diagnosed psychotic disorders. Scores were distress weighted on a scale ranging from…...

2+ week, 3+ day ago  (458+ words) Conexiant...

3+ week, 2+ day ago  (312+ words) The cohort had a mean follow-up of 8. 2 years. Women with premenstrual disorders had a mean age of 35 years at diagnosis. In the matched cohort analysis, 37% of women with premenstrual disorders developed a subsequent psychiatric disorder during follow-up compared with 21% of…...

3+ week, 4+ day ago  (634+ words) The findings, however, should be considered preliminary and hypothesis-generating, according to both the study researchers and an accompanying invited commentary, because the trial included only 40 patients, had no prespecified power calculation, and faced substantial challenges with blinding and treatment attribution....

1+ mon, 3+ week ago  (183+ words) Impulsivity-linked brain patterns identified a subtype with a markedly higher 2-year risk for developing internet gaming disorder. A neuroimaging-defined subtype had a substantially higher 2-year risk for developing internet gaming disorder than a lower-risk subtype, with conversion rates of 24% vs…...

1+ mon, 3+ week ago  (121+ words) When targeted evidence gets diluted, effective treatments for prolonged grief disorder may be harder to see'and use. A JAMA Psychiatry Viewpoint suggests that a major AHRQ review may underrepresent what is already known about prolonged grief disorder'and that gap could…...

2+ mon, 6+ day ago  (419+ words) Randomized trial found more than half of treated patients achieved remission within 8 days. A single-day treatment with inhaled mebufotenin significantly reduced depression severity and led to remission in more than half of patients with treatment-resistant depression by day 8, compared with…...

2+ mon, 1+ week ago  (208+ words) A systematic review and meta-analysis of 24 studies found that psychedelic-assisted therapy was not more effective than traditional antidepressants when compared under open-label conditions. Researchers analyzed data from 8 psychedelic trials (249 patients) and 16 open-label antidepressant trials (7, 921 patients), assessing changes in depression severity…...

2+ mon, 1+ week ago  (209+ words) As a result, observed improvements may reflect a combination of pharmacologic effects, psychological experience, and expectancy. The editorial emphasizes that current trial designs cannot disentangle these components and that the magnitude of placebo effects in depression has no clear upper…...