3+ day, 14+ hour ago   (243+ words) Glioblastoma is a representative form of intractable brain cancer that frequently recurs even after surgery, radiation, and chemotherapy. Immune checkpoint inhibitors have shown only limited effect against the disease. One key reason is that immune cells that infiltrate the tumor…...

3+ day, 18+ hour ago   (128+ words) Table 1: Summary of contamination types in NGS data, with characteristic data signatures and recommended analytical detection tools. Reads with unexpected or mismatched index combinations Unique dual index audit, per-library read-count review A systematic approach for evaluating a sample flagged for…...

3+ day, 20+ hour ago   (727+ words) Weight loss injections are an increasingly popular way for people to manage their weight. However, the injections’ impact on reproductive health – from fertility onwards – is relatively unknown. Manufacturers currently advise that they should be stopped before people try to get…...

3+ day, 18+ hour ago   (156+ words) Mapped 5' start position Mapped start position and UMI sequence Distinguishes independent molecules at the same position Appropriate for WGS germline variant calling Yes, with added overhead Appropriate for deep targeted panel sequencing No; removes genuine fragments Yes, via consensus calling…...

3+ day, 18+ hour ago   (214+ words) Table 1: Common control types in NGS experiments, their diagnostic purpose, and the failure mode each detects. Benchmarks variant calling against an established truth set Run-level instrument failure or cluster density issues Figure 1: In a confounded design, condition and batch are…...

3+ day, 23+ hour ago   (596+ words) More than two decades after scientists first sequenced the entire human genome — all 3 billion “letters,” or base pairs, of DNA code — the meaning of much of this code remains a mystery. Researchers at UC Berkeley have created a new genomic language…...

4+ day, 16+ min ago   (389+ words) Roughly half the world’s population is infected with the stomach bacterium Helicobacter pylori, which is responsible for around 90 per cent of gastric cancers. However, until now, mystery has surrounded the question of why some H. pylori infections lead to a…...