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Semantic encoding of trauma memories in the hippocampus among individuals with PTSD - Neuropsychopharmacology
3+ day, 12+ hour ago (1734+ words) The supplement describes methodology for defining the hippocampus, PCC, and STG ROIs and hippocampus subfields. As validation of the sentence transformer methodology, we examined similarity of semantic embeddings for trauma and neutral sentences (See Supplemental Material and Supplemental Fig. 2). Additionally,…...
Bipolar Disorder And Mood Disorders
9+ mon, 2+ day ago (421+ words) Bipolar disorder, alongside other mood disorders, represents a significant public health challenge that affects millions worldwide. These conditions are marked by dramatic fluctuations in mood, energy. .. Bipolar Disorder And Mood Disorders Bipolar disorder, alongside other mood disorders, represents a significant…...
Obsessive-Compulsive Disorder Research
9+ mon, 2+ day ago (387+ words) Obsessive-compulsive disorder (OCD) remains a major focus of contemporary research, characterised by an emphasis on elucidating its neural mechanisms, neurochemical dynamics, and effective therapeutic. .. Obsessive-compulsive disorder (OCD) remains a major focus of contemporary research, characterised by an emphasis on elucidating…...
Cognitive Impairment in Major Depressive Disorder
9+ mon, 2+ day ago (435+ words) Major Depressive Disorder (MDD) is increasingly recognised not solely as an affective disorder but also as one characterised by enduring cognitive impairments. These deficits, affecting domains such. .. Cognitive Impairment in Major Depressive Disorder Major Depressive Disorder (MDD) is increasingly recognised not solely…...
Adolescent disordered eating and epigenetic age acceleration - Molecular Psychiatry
1+ week, 1+ day ago (1724+ words) Pearson's correlations revealed that global EDE-Q scores calculated at age 14 from the full (18-item) and shortened (11-item) versions were strongly correlated (r=0. 97, p Serial mediation analysis was used to test whether BMI mediated the relationship between restriction at age 14 and…...
Short- and long-term incidence of obsessive'compulsive disorder after objectively recorded potentially traumatic events - Nature Mental Health
1+ week, 2+ day ago (1625+ words) Nature Mental Health (2026)Cite this article Some individuals may have been excluded for more than one reason (for example, missing information on biological parents and emigrating before age six). From this cohort, we subsequently identified clusters of relatives for coaggregation…...
Influence of combined CYP2 C19 and CYP2 D6 phenotypes on adverse drug reactions in patients with major depressive disorder: a clinical cohort study - The Pharmacogenomics Journal
1+ week, 1+ day ago (1698+ words) This study investigates the frequency and intensity of ADR during AD therapy in a cohort of hospitalized psychiatric patients regarding their CYP2 C19 and CYP2 D6 functional status. Pharmacodynamic and pharmacokinetic factors were considered. Furthermore, a drug-specific subgroup analysis was performed for VEN. Patients…...
Direct and indirect parental genetic effects on offspring susceptibility to internalizing problems across development - Nature Mental Health
1+ week, 1+ day ago (1709+ words) Nature Mental Health (2026)Cite this article only $6. 58 per issue Friedrich, M. J. Depression is the leading cause of disability around the world. JAMA 317, 1517 (2017). Bernaras, E. , Jaureguizar, J. & Garaigordobil, M. Child and adolescent depression: a review of theories, evaluation instruments, prevention programs, and treatments. Front. Psychol....
The Cognitive benefits of nitrate in patients with alcohol use disorder: unraveling the oral microbiome ectopic colonization pathway - Molecular Psychiatry
1+ week, 2+ day ago (1816+ words) 16 S r RNA gene sequence data are available in the Sequence Read Archive (SRA) under Bio Project accession PRJNA1127822 and PRJNA1127800. Huang Y, Wang Y, Wang H, Liu Z, Yu X, Yan J, et al. Prevalence of mental disorders in China: a…...
Subjective and neurocognitive profiling of clinical doses of 3, 4-methylenedioxymethamphetamine (MDMA) in healthy volunteers: implications for therapeutic use - Molecular Psychiatry
1+ week, 2+ day ago (1745+ words) A shows alteration in state of consciousness after single doses of MDMA (adapted from [57, 58, 59]). B shows a circular map of subjective effects that are frequently reported after a single dose of MDMA (75125mg) in placebo controlled clinical trials in healthy volunteers....